Quest Clinical Trials Connect

Changing the face of clinical trials today

hero image
Quest Clinical Trials Connect helps bring physicians, patients, and Principal Investigators (PIs) together to support the development of new therapies that can improve the lives of patients everywhere.

For more than 50 years, Quest Diagnostics has been providing insights that lead to more informed healthcare decisions. We help deliver better healthcare today and inspire the innovations of tomorrow.

Our new solution helps drive more cost-effective and timely clinical trials. By connecting the right patients with the right clinical trials at the right time and place, we help move new medicines from vision to reality and bring new hope to patients and their caregivers.

Learn More
 
Quest Clinical Trials Connect helps bring physicians, patients, and Principal Investigators (PIs) together to support the development of new therapies that can improve the lives of patients everywhere.

Why Quest Diagnostics?

The rapidly changing face of medicine offers new opportunities to improve patient health— but moving new medical discoveries through a development pipeline and into market is a time-consuming and expensive endeavor.

A “one size fits all” approach to clinical trials may no longer deliver value or advance healthcare when it comes to diseases like cancer, nonalcoholic steatohepatitis (NASH), Alzheimer’s disease, and more.

Ongoing challenges in clinical trials—recruiting the right patients, controlling costs, building relationships with physicians, and validating sites—drive a need for solutions that help bring innovative new treatments to patients who need them.

A “one size fits all” approach to clinical trials may no longer deliver value or advance healthcare when it comes to diseases like cancer, nonalcoholic steatohepatitis (NASH), Alzheimer’s disease, and more.

Quest has relationships throughout healthcare—pharma, patients, physicians, health plans, and health systems—uniquely positioning us to make the connections needed to drive more effective clinical trials.

Because less than 25% of patients report learning about clinical trials from their doctor, our ability to communicate directly with patients can help provide a potential new care option, bridging a critical gap in care.1

hero image
 

Some of the advantages
Quest brings to clinical trials include:

Direct to patient and provider relationships reaching 1/3 of the US adult population each year and half the country’s physicians and hospitals
A broad geographic reach via a network of more than 2,200 Patient Service Centers, with increasing retail presence with locations in Walmart® and Safeway
The most comprehensive advanced diagnostics test portfolio in existence, with ongoing R&D in companion diagnostics and in-home testing
Collaborations with a wide range of leading healthcare organizations
Over 8 years of longitudinal patient history
Q2 Solutions®, a joint venture between Quest Diagnostics and IQVIA provides central laboratory services to support clinical development programs
8+

years of longitudinal patient history

>40B

lab events

 
>15k

mobile care professionals

650

MDs and
PhDs for consultation

 

The Challenge

Fundamental changes in the healthcare ecosystems have made clinical trials complex, costly, and lengthy

Clinical trial enrollment has historically been impeded by a number of factors. Few patients are aware of clinical trial opportunities and most clinicians do not participate in research.

The challenge–bringing more connections and efficiency to the intersection of patients, providers, and sponsors

Even when patients do learn of a clinical trial opportunity from their doctor or from an advertisement, they often find participation inconvenient or difficult because of the location of the clinical trial site.

Adding to the geographic challenge, the increasing complexity of clinical inclusion and exclusion criteria makes it more difficult to identify the “right” patient for any given study. Many patients become ineligible during pre-screening due to exclusionary conditions or medications.

Doctor talking to patient

Patient identification and pre-screening are the most challenging steps in patient recruitment, accounting for the majority of the budget in clinical trial recruitment

Patient outreach often includes advertising and referral networksthat involve contact with thousands of potential patients just to find ~100 interested patients

Patient outreach near sites include advertising...
Sepaarator
 

Reference:
2 Harper, B. Effective Strategies for Patient Recruitment and Retention. Ucdmc.ucdavis.edu. https://www.ucdmc.ucdavis.edu/clinicaltrials/Training/documents/2014/CRC3/2.2%20Effective%20Strategies%20for%20Patient%20Recruitment%20and%20Retention_POST.pdf. December 5, 2014. Accessed June 8, 2018.

Clinical trials have become more complex

Research conducted by the Tufts Center for the Study of Drug Development (CSDD) during the past 15 years has demonstrated that, compared to 10 years ago, protocols have more endpoints, procedures, eligibility criteria, CRF (case report form) pages, amendments, and investigative sites.3

Over the past 15 years, eligibility criteria soared, while the total number of procedures went from 97 to 163.4

Eligibility Criteria
Quest meets the challenge by simplifying clinical trials

The increase in protocol complexity affects sponsors, sites/investigators, and patients. By identifying pre-qualified patients upfront, through inclusion/exclusion criteria, Quest should be able to:

Increase the likelihood that the patient will qualify for a study in which they are interested
Reduce the likelihood that the patient will screen fail and thereby reduce site burden by sending fewer, but more qualified patients
Save the sponsor time and money by reducing the number of screening visits
 

References:
3 Morgan C. Managing increasing complexity in the clinical trial industry. goBalto. https://www.gobalto.com/blog/managing-increasing-complexity-in-the-clinical-trial-industry. August 15, 2016. Accessed June 1, 2018.
4 Miseta E. Getz: Site Activations Hurt by Commodity Mentality. Clinical Leader. https://www.clinicalleader.com/doc/getz-site-activations-hurt-by-commodity-mentality-0001. May 16, 2016. Accessed June 1, 2018.

Clinicians and patients don't always know about the trial

Only 33% of U.S. adults have heard of clinical trials, and of those, fewer than 5% know where to find information about them.5

While 80% of the public consider their physician recommendation very important to participating in a clinical trial, only 23% say a health professional has talked to them about it.6

87% of physicians are not currently involved in conducting clinical trials.7

80%/23%
Physicians not involved
Quest meets the challenge by leveraging our existing relationships

By leveraging our existing relationships with patients and their physicians, we are able to reach out directly to those patients who have not opted out, or their physicians, and provide information about clinical trials that may be of interest.

 

References:
5 Monteleone J. Patient Recruitment: Clinical research’s “White Whale”?. LinkedIn. https://www.linkedin.com/pulse/patient-recruitment-clinical-researchs-white-whale-jason? articleId=7103206211285145337. December 12, 2016. Accessed June 1, 2018.
6 The Center for Information & Study on Clinical Research Participation. ARCHIVED clinical research facts and figures for health professionals. http://0393122.netsolhost.com/wp-content/uploads/2014/03/ciscrp_data_archive_facts_and_figures_for_health_professionals.pdf. Accessed June 1, 2018.
7 Desvigne-Nickens P. Clinical trial enrollment: NIH experience. https://www.fda.gov/ucm/groups/fdagov-public/@fdagov-meddev-gen/documents/document/ucm360965.pdf. June 24, 2013. Accessed June 1, 2018.

Low enrollment: a complex problem

Often, clinical trial enrollment is hampered by increasingly complex inclusion or exclusion criteria and inefficient site selection.

15%-20% of trials never enroll a single patient.8

 
20% Doctor
Quest meets the challenge by focusing on the right patients in the right places at the right time

Utilizing protocol inclusion/exclusion criteria, we can identify the geographies in which there are the greatest potential patient population. Quest may:

Compare data results with sponsor site list to validate sites and investigators
Identify additional clinicians with concentrations of potential patients and utilize current relationships to determine interest in clinical trial participation or potential patient referral to existing sites

This allows studies to focus on the right sites/investigators with profiled patient populations, thereby helping to reduce or eliminate low enrolling sites in a given study.

 

Reference:
8 Lo C. The numbers game: boosting clinical trial enrollment. Pharmaceutical Technology. https://www.pharmaceutical-technology.com/features/featurethe-numbers-game-boosting-clinical-trial-enrolment-4171654/. February 5, 2014. Accessed June 1, 2018.

Fundamental changes in the healthcare ecosystems have made clinical trials complex, costly, and lengthy

Doctor talking to patient

Clinical trial enrollment has historically been impeded by a number of factors. Few patients are aware of clinical trial opportunities and most clinicians do not participate in research.

Even when patients do learn of a clinical trial opportunity from their doctor or from an advertisement, they often find participation inconvenient or difficult because of the location of the clinical trial site.

The challenge–bringing more connections and efficiency to the intersection of patients, providers, and sponsors

Adding to the geographic challenge, the increasing complexity of clinical inclusion and exclusion criteria makes it more difficult to identify the “right” patient for any given study. Many patients become ineligible during pre-screening due to exclusionary conditions or medications.

Patient identification and pre-screening is the most challenging step in patient recruitment and accounts for the majority of the budget in a clinical trial

Patient outreach often includes advertising and referral networksthat involve contact with thousands of potential patients just to find ~100 interested patients

 
Patient outreach near sites include advertising...
 

Reference:
2 Harper, B. Effective Strategies for Patient Recruitment and Retention. Ucdmc.ucdavis.edu. https://www.ucdmc.ucdavis.edu/clinicaltrials/Training/documents/2014/CRC3/2.2%20Effective%20Strategies%20for%20Patient%20Recruitment%20and%20Retention_POST.pdf. December 5, 2014. Accessed June 8, 2018.

Clinical trials have become more complex

Research conducted by the Tufts Center for the Study of Drug Development (CSDD) during the past 15 years has demonstrated that, compared to 10 years ago, protocols have more endpoints, procedures, eligibility criteria, CRF (case report form) pages, amendments, and investigative sites.3

Over the past 15 years, eligibility criteria soared, while the total number of procedures went from 97 to 163.4

Eligibility Criteria
 
Quest meets the challenge by simplifying clinical trials

The increase in protocol complexity affects sponsors, sites/investigators, and patients. By identifying pre-qualified patients upfront, through inclusion/exclusion criteria, Quest should be able to:

Increase the likelihood that the patient will qualify for a study in which they are interested
Reduce the likelihood that the patient will screen fail and thereby reduce site burden by sending fewer, but more qualified patients
Save the sponsor time and money by reducing the number of screening visits
 

References:
3 Morgan C. Managing increasing complexity in the clinical trial industry. goBalto. https://www.gobalto.com/blog/managing-increasing-complexity-in-the-clinical-trial-industry. August 15, 2016. Accessed June 1, 2018.
4 Miseta E. Getz: Site Activations Hurt by Commodity Mentality. Clinical Leader. https://www.clinicalleader.com/doc/getz-site-activations-hurt-by-commodity-mentality-0001. May 16, 2016. Accessed June 1, 2018.

Clinicians and patients don’t always know about the trial

Only 33% of U.S. adults have heard of clinical trials, and of those, fewer than 5% know where to find information about them.5

While 80% of the public consider their physician recommendation very important to participating in a clinical trial, only 23% say a health professional has talked to them about it.6

87% of physicians are not currently involved in conducting clinical trials.7

80%/23%
Physicians not involved
 
Quest meets the challenge by leveraging our existing relationships

By leveraging our existing relationships with patients and their physicians, we are able to reach out directly to those patients who have not opted out, or their physicians, and provide information about clinical trials that may be of interest.

 

References:
5 Monteleone J. Patient Recruitment: Clinical research’s “White Whale”?. LinkedIn. https://www.linkedin.com/pulse/patient-recruitment-clinical-researchs-white-whale-jason? articleId=7103206211285145337. December 12, 2016. Accessed June 1, 2018.
6 The Center for Information & Study on Clinical Research Participation. ARCHIVED clinical research facts and figures for health professionals. http://0393122.netsolhost.com/wp-content/uploads/2014/03/ciscrp_data_archive_facts_and_figures_for_health_professionals.pdf. Accessed June 1, 2018.
7 Desvigne-Nickens P. Clinical trial enrollment: NIH experience. https://www.fda.gov/ucm/groups/fdagov-public/@fdagov-meddev-gen/documents/document/ucm360965.pdf. June 24, 2013. Accessed June 1, 2018.

Low enrollment: a complex problem

Often, clinical trial enrollment is hampered by increasingly complex inclusion or exclusion criteria and inefficient site selection.

15%-20% of trials never enroll a single patient.8

 
Doctor
 
Quest meets the challenge by focusing on the right patients in the right places at the right time

Utilizing protocol inclusion/exclusion criteria, we can identify the geographies in which there are the greatest potential patient population. Quest may:

Compare data results with sponsor site list to validate sites and investigators
Identify additional clinicians with concentrations of potential patients and utilize current relationships to determine interest in clinical trial participation or potential patient referral to existing sites

This allows studies to focus on the right sites/investigators with profiled patient populations, thereby helping to reduce or eliminate low enrolling sites in a given study.

 

Reference:
8 Lo C. The numbers game: boosting clinical trial enrollment. Pharmaceutical Technology. https://www.pharmaceutical-technology.com/features/featurethe-numbers-game-boosting-clinical-trial-enrolment-4171654/. February 5, 2014. Accessed June 1, 2018.


The Quest solution

Quest Clinical Trials Connect is reinventing clinical trials

We connect patients and physicians to clinical trial sponsors and clinical research organizations (CROs) to help drive more effective and efficient clinical trials. Starting with powerful relationships in healthcare, Quest is building a complete, end-to-end integrated platform that’s scalable and secure.

hero image

Efficient patient and physician recruitment and site validation are available today through Quest Clinical Trials Connect, and the solution is designed to grow with evolving demand, leading to a broad solution for cohort profiling, patient-initiated pre-screening, and virtual trials.

Quest Clinical Trials Connect includes:

Time-saving process to identify and recruit patients for trials
Efficient search and recruitment that can help deliver better results and better qualified patients
New ways to create and service virtual trials that look beyond the traditional challenges of fixed trial sites and capacity issues
A unique data set, with 40 billion test results covering 190 million patient lives and drawing from a relationship with half of US physicians and hospitals
Quest Solution
Using insights to make clinical trial connections
Quest Clinical Trials Connect brings patient, physician, investigator, and other third-party data together to evaluate eligibility, enroll patients, and stay continually engaged through the clinical trial process.
 

Quest Clinical Trials Connect is a multi-phase program designed to provide a complete, end-to-end solution that will include cohort analysis, trial design scenario planning, patient recruitment execution and analytics, and patient engagement. It is supported with personalized management dashboards and reporting tools to help measure and deliver value and impact.

Quest Clinical Trials Connect features to be included:

Scalable architecture that can flex with trial complexity, geographic reach, evolutionary functionality, and inter-operability
A secure, cloud-based solution that grows infrastructure and cost with evolving demand
A collaborative approach to source subject matter expertise, platform algorithms, and data
Machine learning measurement and analysis that builds an increasingly effective solution
A solution engineered to measure and deliver value and impact, as defined by the sponsor
 

Quest Clinical Trials Connect

Our current service offerings are focused around trial logistics and recruitment:

Site/PI validation & identification
Direct-to-patient outreach
Physician outreach

Future service offerings will include these and others:

Cohort profiling and analytics
Patient initiated testing (pre-screening)
Decentralized trials - hybrid and virtual
 
locator icon

Site/Investigator validation and identification

Using the inclusion/exclusion criteria set, we can validate matched potential patient volumes to sites and investigators and help identify additional physicians with concentrations of potential patients

map-image
Inputs, Deliverables to Enrolled Patients
Inputs, Deliverables to Enrolled Patients
Benefits
Help locate best clinical trial sites for optimal outreach to patients of interest
Identify additional physicians as investigators or patient recruitment sources
Instill confidence in selected sites/investigators
purple head icon

Direct patient screening

We connect patients with study opportunities.

Inputs, Deliverables, Enrolled Patients
Benefits
Personalized outreach for a more effective recruitment program
Increase pre-screening efficiency to lower screening burden and early attrition
Engage patients most likely to participate through study completion
Personalize and promote care recommendations
map-image
locator icon

Physician outreach

Identify physicians and their patients who might qualify for clinical trials and inform them of the opportunity

Inputs, Deliverables, Enrolled Patients Inputs, Deliverables, Enrolled Patients
Benefits
Engage existing Quest network on physician relationships
Help build connections between clinicians and study investigators to facilitate patient engagement
Introduce clinical trials as a potential care option for patients
Help increase care community awareness of clinical trial options for patients

The platform

Quest Clinical Trials Connect combines deep data science, advanced machine learning, and powerful search capabilities to provide an analytics and partner platform to benefit sponsors and investigators, opted-in patients, and physicians.

 

Personalized access

Quest Clinical Trials Connect is a secure, end-to-end, cloud-based portal with personalized access.

Personalized access

Personalized access

Quest Clinical Trials Connect is a secure, end-to-end, cloud-based portal with personalized access.

 
Consented patient tracking

Consented patient tracking

This secure, scalable portal cultivates and tracks consented relationships with patients and their physicians, making the data and analytics actionable in a HIPAA-compliant way.

Consented patient tracking

This secure, scalable portal cultivates and tracks consented relationships with patients and their physicians, making the data and analytics actionable in a HIPAA-compliant way.

 
 
 

Unlocking the future of patient-centered trials

 
hero image

Site validation, patient recruitment, and physician recruitment solutions are only the first step in our goal of bringing clinical trials forward as a new avenue of treatment to improve the health of patients. We are reimagining clinical trial design so that in the future we can incorporate:

Direct-to-patient trials that can leverage in-home self-administered testing and mobile care teams, who can administer therapeutics, collect samples, and capture biometric data
Quest Patient Service Centers as potential screening sites and interim check-points
Virtual Principal Investigators (PIs) or sub-PIs

At the same time, we continue to make advancements in patient-centered recruitment, including:

Enriched identified data sets
Advanced cohort analytics
Enrollment and retention experience-based outreach
family picture

Quest is committed to developing innovative solutions and relationships that can help accelerate the time to market of new therapeutics. By making connections between patients, physicians and sponsors, together we can bring new hope to patients and their loved ones.

 

Talk to Us

Find out what Quest Clinical Trials Connect can do for you, and start changing the face of your clinical trial. Contact us to learn more at CTConnect@QuestDiagnostics.com

* Required

 

You can opt out of receiving information about clinical trial opportunities.

Thank you

Someone from Quest Diagnostics will contact you shortly.

Two doctors reviewing chart Two doctors reviewing chart